Obesity is a pandemic condition of complex etiology, resulting from the increasing exposition
to obesogenic environmental factors combined with genetic susceptibility. In the past two�…

Obesity is associated with increased morbidity and mortality from cardiovascular disease,
diabetes mellitus and certain cancers. The prevalence of obesity is increasing rapidly�…

The discovery of leptin has provided a robust framework upon which our current
understanding of the mechanisms involved in energy homeostasis has been built. In this�…

Monogenic obesity is a severe, genetically determined disorder that affects up to 1/1000
newborns. Recent reports on potential new therapeutics and innovative clinical approaches�…

We have previously demonstrated that genetically based leptin deficiency due to a missense
leptin gene mutation in a highly consanguineous extended Turkish pedigree is associated�…

Obesity results from a synergistic relationship between genes and the environment. The
phenotypic expression of genetic factors involved in obesity is variable, allowing to�…

Leptin has emerged over the past decade as a key hormone in not only the regulation of
food intake and energy expenditure but also in the regulation of neuroendocrine and�…

Considerable attention has focused on deciphering the hypothalamic pathways that mediate
the behavioral and metabolic effects of leptin. We and others have identified several single�…

The role of genetic factors involved in the etiology of human obesity is beyond question. The
identification of the hypothalamic leptin-melanocortin signaling pathway as a critical�…

Context Homozygous leptin (LEP) and leptin receptor (LEPR) variants lead to childhood-
onset obesity. Objective To present new cases with LEP and LEPR deficiency, report the�…