Interactions between the hippocampus and the cortex are critical for memory. Interictal
epileptiform discharges (IEDs) identify epileptic brain regions and can impair memory, but�…

We describe the spatiotemporal course of cortical high-gamma activity, hippocampal ripple
activity and interictal epileptiform discharges during an associative memory task in 15�…

Dynamic interactions between remote but functionally specialized brain regions enable
complex information processing. This intercortical communication is disrupted in the neural�…

For more than a decade, there has been extensive discussion about whether hippocampal
sclerosis causes enhanced neuronal excitability as a prerequisite for seizure generation�…

Objective: We investigated whether interictal epileptiform discharges (IED) in the human
hippocampus are related to impairment of specific memory processes, and which�…

The mechanism of seizure emergence and the role of brief interictal epileptiform discharges
(IEDs) in seizure generation are two of the most important unresolved issues in modern�…

The mechanisms involved in the transition to an epileptic seizure remain unclear. To
examine them, we used tissue slices from human subjects with mesial temporal lobe�…

The origin and mechanisms of human interictal epileptic discharges remain unclear. Here,
we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients�…

Interictal and ictal discharges are recorded from limbic structures in temporal lobe epilepsy
patients. In clinical practice, interictal spikes are used to localize the epileptogenic area, but�…

Objective Cognitive impairment is common in epilepsy, particularly in memory function.
Interictal spikes (IISs) are thought to disrupt cognition, but it is difficult to delineate their�…