Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG�…

Voltage-gated sodium channels (VGSCs) are the basic ion channels for neuronal
excitability, which are crucial for the resting potential and the generation and propagation of�…

Dravet syndrome (DS) is an intractable developmental and epileptic encephalopathy
caused largely by de novo variants in the SCN1A gene, resulting in haploinsufficiency of the�…

Objectives To establish standards for early, cost-effective, and accurate diagnosis; optimal
therapies for seizures; and recommendations for evaluation and management of�…

Dravet syndrome (DS) is a severe epileptic encephalopathy caused mainly by heterozygous
loss-of-function mutations of the SCN1A gene, indicating haploinsufficiency as the�…

Abstract Introduction Both Δ9 Tetrahydrocannabidiol (THC) and cannabidiol (CBD)
components of cannabis, have been shown to have anticonvulsant effects. Cannabis oils�…

Abstract The Dravet Syndrome Foundation (DSF) conducted the largest in-depth survey of
parents and caregivers of patients with Dravet syndrome (DS) to date, in order to (1) identify�…

Voltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation
of action potentials in excitable cells. VGSCs in mammalian brain are heterotrimeric�…

Introduction Premature mortality is a major issue in Dravet syndrome (DS). To improve
understanding of DS premature mortality, we conducted a comprehensive literature search�…

Intracellular accumulation of TAU aggregates is a hallmark of several neurodegenerative
diseases. However, global genetic reduction of TAU is beneficial also in models of other�…