There has been, and continues to be, a dramatic shift in the human population towards older
ages necessitating biomedical research aimed at better understanding the basic biology of�…

Recent studies suggest that being overweight or obese is related to worse cognitive
performance, particularly executive function. Obesity may also increase the risk of�…

Aging is the biological process of declining physiologic function associated with increasing
mortality rate during advancing age. Humans and higher nonhuman primates exhibit�…

Historically, cancer research has focused on identifying mutations or amplification of genes
within the tumor, which informed the development of targeted therapies against affected�…

ABSTRACT Introduction: Pathophysiological mechanisms underlying Alzheimer's disease
(AD) remain insufficiently documented for the identification of accurate diagnostic markers�…

Higher systemic levels of the proinflammatory cytokine interleukin-6 (IL-6) were found to be
associated with lower gray matter volume and tissue density in old rhesus macaques. This�…

A significant portion of our risk for dementia in old age is associated with lifestyle factors
(diet, exercise, and cardiovascular health) that are modifiable, at least in principle. One such�…

Background: During fetal and perinatal periods, many nutrients, such as long-chain
polyunsaturated fatty acids [contained in fish oil (FO)] and folate, are important in achieving�…

Hypertension with high homocysteine (Hcy,≥ 10 μmol/L) is also known as H-type
hypertension (HHT) and proposed as an independent risk factor for stroke and cognitive�…

The aged rhesus macaque exhibits brain atrophy and behavioral deficits similar to normal
aging in humans. Here we studied the association between cognitive and motor�…