Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The�…

Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling�…

The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory�…

Tau protein can transfer between neurons transneuronally and trans-synaptically, which is
thought to explain the progressive spread of tauopathy observed in the brain of patients with�…

Various mechanisms in the mammalian body provide resilience against food deprivation
and dietary stress. The ketone body β-hydroxybutyrate (BHB) is synthesized in the liver from�…

Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in
humans, but still no curative treatment has been developed. Although many explicative�…

Alzheimer's disease is a progressive loss of memory and cognition, for which there is no
cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's�…

Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in�…

Epileptic activity is frequently associated with Alzheimer's disease; this association has
therapeutic implications, because epileptic activity can occur at early disease stages and�…

Importance Network hyperexcitability may contribute to cognitive dysfunction in patients with
Alzheimer disease (AD). Objective To determine the ability of the antiseizure drug�…