Abstract The 2017 International League Against Epilepsy classification has defined a three‐
tier system with epilepsy syndrome identification at the third level. Although a syndrome�…

Tuberous sclerosis complex is a rare genetic disease associated with mutations in the TSC1
or TSC2 genes, which cause overactivation of the mTOR complex. In the past 5 years�…

Epileptogenesis in infants with tuberous sclerosis complex (TSC) is a gradual and dynamic
process, leading to early onset and difficult-to-treat seizures. Several cellular, molecular and�…

Epilepsy is a paroxysmal brain disorder that results from an imbalance between neuronal
excitation and inhibition. Gamma-aminobutyric acid (GABA) is the most important inhibitory�…

Neuropsychiatric and Cognitive Comorbidities in Epilepsy : CONTINUUM: Lifelong
Learning in Neurology Account Register Activate Subscription Help Subscribe American�…

CDKL5 deficiency disorder (CDD) is an X-linked brain disorder of young children and is
caused by pathogenic variants in the cyclin-dependent kinase-like 5 (CDKL5) gene�…

Cenobamate (CNB),([(R)-1-(2-chlorophenyl)-2-(2H-tetrazol-2-yl) ethyl], is a novel tetrazole
alkyl carbamate derivative. In November 2019, the Food and Drug Administration approved�…

Epilepsy is one of the most common neurological disorders. Although many factors
contribute to epileptogenesis, seizure generation is mostly linked to hyperexcitability due to�…

The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure.
The sigma-2 receptor is a genetically unrelated protein with a similarly shaped binding�…

Background The developmental and epileptic encephalopathies (DEEs) are the most severe
group of epilepsies which co-present with developmental delay and intellectual disability�…