It is important that the medical profession play a significant role in critically evaluating the
use of diagnostic procedures and therapies as they are introduced and tested in the�…

Heart failure (HF) is a major and growing public health problem in the United States.
Approximately 5 million patients in this country have HF, and over 550 000 patients are�…

OBJECTIVE: Most research on the effects of severe psychological stress has focused on
stress-related psychopathology. Here, the author develops psychobiological models of�…

Heart failure is a syndrome characterized initially by left ventricular dysfunction that triggers
countermeasures aimed to restore cardiac output. These responses are compensatory at�…

Heart failure (HF), the leading cause of death in the western world, develops when a cardiac
injury or insult impairs the ability of the heart to pump blood and maintain tissue perfusion. It�…

From fundamental principles to advanced subspecialty procedures, Miller's Anesthesia
covers the full scope of contemporary anesthesia practice. This go-to medical reference�…

resultant striking increase in morbidity and mortality. The transition to symptomatic heart
failure is accompanied by further activation of neurohormonal and cytokine systems, as well�…

This review addresses open questions about the role of β-adrenergic receptors in cardiac
function and failure. Cardiomyocytes express all three β-adrenergic receptor subtypes—β1�…

Psychological stress elicits measurable changes in sympathetic-parasympathetic balance
and the tone of the hypothalamic-pituitary-adrenal axis, which might negatively affect the�…

Enormous progress in mapping complex traits in humans has been made in the last 5 yr.
There has been early success for prevalent diseases with complex phenotypes. These�…