MicroRNAs are short noncoding RNA regulators that repress synthesis of their targets post‐
transcriptionally. On average, each microRNA is estimated to regulate several hundred�…

Abstract p53 is a major regulator of cell cycle arrest, apoptosis, and senescence. While
involvement of p53 in tumorigenesis is well established, recent studies implicate p53 in the�…

Fibrosis is the leading cause of organ dysfunction in diseases such as systemic sclerosis,
liver cirrhosis, cardiac fibrosis, progressive kidney disease, and idiopathic pulmonary�…

Ethanol-mediated inhibition of hepatic sirtuin 1 (SIRT1) plays a crucial role in the
pathogenesis of alcoholic fatty liver disease. Here, we investigated the underlying�…

Mature microRNAs (miRNAs) are single-stranded RNAs with approximately 18–25 bases,
and their sequences are highly conserved among animals. miRNAs act as�…

We previously observed association between variants in the plasmacytoma variant
translocation 1 gene (PVT1) and end-stage renal disease (ESRD) attributed to both type 1�…

Diabetic nephropathy is one of the most common and severe complications of diabetes
mellitus, affecting one in every five patients suffering from diabetes. Despite extensive�…

Integrins are cellular receptors that bind the extracellular matrix (ECM) and facilitate the
transduction of biochemical and biophysical microenvironment cues into cellular responses�…

Organ fibrosis represents a dysregulated, maladaptive wound repair response that results in
progressive disruption of normal tissue architecture leading to detrimental deterioration in�…

Circular RNAs (circRNAs) act as competing endogenous RNAs, which are involved in the
regulation of many types of cancers. They primarily function by sponging microRNAs�…