TGF-β1–induced expression of extracellular matrix (ECM) genes plays a major role in the
development of chronic renal diseases such as diabetic nephropathy. Although many key�…

Increased morbidity and mortality associated with ischemic heart failure (HF) in type 2
diabetic patients requires a deeper understanding of the underpinning pathogenetic�…

MicroRNAs contribute to the development of kidney disease. Previous analyses of
microRNA expression in human kidneys, however, were limited by tissue heterogeneity or�…

MicroRNAs (miRNAs) are small, noncoding RNAs of 18–25 nucleotides that are generally
believed to either block the translation or induce the degradation of target mRNA. miRNAs�…

MicroRNAs (miRNAs) are small 19–23 nucleo-tide RNA molecules that act as regulators of
protein expression in eukaryotic cells by inducing the translational arrest and degradation of�…

There has been a rapid increase in the incidence of diabetes as well the associated
vascular complications. Both genetic and environmental factors have been implicated in�…

The majority of melanomas show constitutive activation of the RAS-RAF-MAP/ERK kinase
(MEK)-mitogen-activated protein kinase (MAPK) pathway. AZD6244 is a selective MEK1/2�…

Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC). However, the
mechanism underlying the progression from cirrhosis to HCC remains unclear. Herein we�…

Aberrantly expressed microRNA (miRNA) is frequently associated with a variety of cancers,
including pancreatic ductal adenocarcinoma (PDAC). In this study, we investigated the�…

The detection of acute kidney injury (AKI) and the monitoring of chronic kidney disease
(CKD) is becoming more important in industrialized countries. Because of the direct relation�…