Presenilins play essential roles in memory formation, synaptic function, and neuronal
survival. Mutations in the Presenilin-1 (PSEN1) gene are the major cause of familial�…

The Cre-loxP system is invaluable for spatial and temporal control of gene knockout,
knockin, and reporter expression in the mouse nervous system. However, we report varying�…

A psychotherapeutic regimen that uses alternating bilateral sensory stimulation (ABS) has
been used to treat post-traumatic stress disorder. However, the neural basis that underlies�…

The CA2 region of the hippocampus is a somewhat obscure area lacking in an
understanding of its form and function. Until recently, the CA2 has been thought of as merely�…

Pattern separation and pattern completion processes are central to how the brain processes
information in an efficient manner. Research into these processes is escalating and deficient�…

The hippocampal formation is essential for the processing of episodic memories for
autobiographical events that happen in unique spatiotemporal contexts. Interestingly, before�…

Availability of genome-scale in situ hybridization data allows systematic analysis of genetic
neuroanatomical architecture. Within the hippocampus, electrophysiology and lesion and�…

Place-specific firing in the hippocampus is determined by path integration-based spatial
representations in the grid-cell network of the medial entorhinal cortex. Output from this�…

A role for norepinephrine in learning and memory has been elusive and controversial. A
longstanding hypothesis states that the adrenergic nervous system mediates enhanced�…

Most molecular and cellular studies of cognitive function have focused on either normal or
pathological states, but recent research with transgenic mice has started to address the�…