Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate�…

Learning and memory are two of the most magical capabilities of our mind. Learning is the
biological process of acquiring new knowledge about the world, and memory is the process�…

The hippocampal-entorhinal system is important for spatial and relational memory tasks. We
formally link these domains, provide a mechanistic understanding of the hippocampal role in�…

The ability to find one's way depends on neural algorithms that integrate information about
place, distance and direction, but the implementation of these operations in cortical�…

The ability to discriminate among similar experiences is a crucial feature of episodic
memory. This ability has long been hypothesized to require the hippocampus, and�…

The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG
lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating�…

We update complementary learning systems (CLS) theory, which holds that intelligent
agents must possess two learning systems, instantiated in mammalians in neocortex and�…

Genetically engineered mouse models are commonly preferred for studying the human
disease due to genetic and pathophysiological similarities between mice and humans. In�…

More than three decades of research have demonstrated a role for hippocampal place cells
in representation of the spatial environment in the brain. New studies have shown that place�…

Significant progress has been made in understanding the neurobiological mechanisms
through which exercise protects and restores the brain. In this feature review, we integrate�…