Vitamin C is an antioxidant that may scavenge reactive oxygen species preventing DNA
damage and other effects important in cancer transformation. Dietary vitamin C from natural�…

The link between chronic inflammation and cancer involves cytokines and mediators of
inflammatory pathways. Cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism�…

Vitamin C (ascorbic acid) plays important roles as an anti-oxidant and in collagen synthesis.
These important roles, and the relatively large amounts of vitamin C required daily, likely�…

Ever since Linus Pauling published his studies, the effects of vitamin C have been
surrounded by contradictory results. This may be because its effects depend on a number of�…

Introduction 3. Vitamin C in humans: adsorption, deficiency, excess 4. Mechanisms of action
of Vitamin C 4.1. Collagen synthesis 4.2. Regulation of hypoxia-inducible factor 1α 4.3�…

Aging is an inevitable universal biological process, which can be characterized by a general
decline in physiological function with the accumulation of diverse adverse changes and�…

Stress-related disorders, such as depression and anxiety, present marked deficits in
behavioral and cognitive functions related to reward. These are highly prevalent disabling�…

Ascorbate is a cofactor in numerous metabolic reactions. Humans cannot synthesize
ascorbate owing to inactivation of the gene encoding the enzyme l-gulono-γ-lactone�…

The production of phenotype is regulated by differential gene expression. However, the
regulators of gene expression need not all reside within the embryo. Environmental factors�…

Ferulic acid is a potent ubiquitous plant antioxidant. Its incorporation into a topical solution of
15% L-ascorbic acid and 1% α-tocopherol improved chemical stability of the vitamins (C+ E)�…