This narrative review aims to pinpoint mental and behavioral effects of starvation, which may
be triggered by hypoleptinemia and as such may be amenable to treatment with leptin�…

Obesity is a complex and heterogeneous condition that leads to various metabolic
complications, including type 2 diabetes. Unfortunately, for some, treatment options to date�…

The peripheral nervous system harbors a remarkable potential to regenerate after acute
nerve trauma. Full functional recovery, however, is rare and critically depends on peripheral�…

The adipokine Leptin activates its receptor LEP-R in the hypothalamus to regulate body
weight and exerts additional pleiotropic functions in immunity, fertility and cancer. However�…

The continued global increase in the prevalence of obesity prompted a meeting at the Royal
Society of London investigating causal mechanisms of the disease,'Causes of obesity�…

Background Obesity is a multifactorial chronic disease with a high, increasing worldwide
prevalence. Genetic causes account for 7% of the cases in children with extreme obesity�…

Abstract Purpose of Review Enormous progress has been made in understanding the
genetic architecture of obesity and the correlation of epigenetic marks with obesity and�…

Context Homozygous leptin (LEP) and leptin receptor (LEPR) variants lead to childhood-
onset obesity. Objective To present new cases with LEP and LEPR deficiency, report the�…

The increase in the prevalence of overweight, obesity and associated diseases is a serious
problem. The aim of the study was to identify rare variants in obesity-associated genes in�…

Two psychiatric interviews of a 39-year old female with congenital leptin deficiency were
conducted to define psychological changes 14 and 165 days after initiation of treatment with�…