Sudden unexpected death in epilepsy: epidemiology, mechanisms, and prevention
O Devinsky, DC Hesdorffer, DJ Thurman…�- The Lancet�…, 2016 - thelancet.com
Sudden unexpected death in epilepsy (SUDEP) can affect individuals of any age, but is most
common in younger adults (aged 20–45 years). Generalised tonic-clonic seizures are the�…
common in younger adults (aged 20–45 years). Generalised tonic-clonic seizures are the�…
SCN1A‐related phenotypes: epilepsy and beyond
IE Scheffer, R Nabbout�- Epilepsia, 2019 - Wiley Online Library
SCN1A, encoding the alpha 1 subunit of the sodium channel, is associated with several
epilepsy syndromes and a range of other diseases. SCN1A represents the archetypal�…
epilepsy syndromes and a range of other diseases. SCN1A represents the archetypal�…
ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions
SM Zuberi, E Wirrell, E Yozawitz, JM Wilmshurst…�- …, 2022 - Wiley Online Library
Abstract The International League Against Epilepsy (ILAE) Task Force on Nosology and
Definitions proposes a classification and definition of epilepsy syndromes in the neonate�…
Definitions proposes a classification and definition of epilepsy syndromes in the neonate�…
Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome
Worldwide medicinal use of cannabis is rapidly escalating, despite limited evidence of its
efficacy from preclinical and clinical studies. Here we show that cannabidiol (CBD)�…
efficacy from preclinical and clinical studies. Here we show that cannabidiol (CBD)�…
Dose-ranging effect of adjunctive oral cannabidiol vs placebo on convulsive seizure frequency in Dravet syndrome: a randomized clinical trial
I Miller, IE Scheffer, B Gunning…�- JAMA�…, 2020 - jamanetwork.com
Importance Clinical evidence supports effectiveness of cannabidiol for treatment-resistant
seizures in Dravet syndrome, but this trial is the first to evaluate the 10-mg/kg/d dose�…
seizures in Dravet syndrome, but this trial is the first to evaluate the 10-mg/kg/d dose�…
Autistic-like behaviour in Scn1a+/− mice and rescue by enhanced GABA-mediated neurotransmission
Haploinsufficiency of the SCN1A gene encoding voltage-gated sodium channel NaV1. 1
causes Dravet's syndrome, a childhood neuropsychiatric disorder including recurrent�…
causes Dravet's syndrome, a childhood neuropsychiatric disorder including recurrent�…
Sodium channelopathies in neurodevelopmental disorders
The voltage-gated sodium channel α-subunit genes comprise a highly conserved gene
family. Mutations of three of these genes, SCN1A, SCN2A and SCN8A, are responsible for a�…
family. Mutations of three of these genes, SCN1A, SCN2A and SCN8A, are responsible for a�…
Optimizing the diagnosis and management of Dravet syndrome: recommendations from a North American consensus panel
EC Wirrell, L Laux, E Donner, N Jette, K Knupp…�- Pediatric�…, 2017 - Elsevier
Objectives To establish standards for early, cost-effective, and accurate diagnosis; optimal
therapies for seizures; and recommendations for evaluation and management of�…
therapies for seizures; and recommendations for evaluation and management of�…
Seizures in children
A Fine, EC Wirrell�- Pediatrics in review, 2020 - publications.aap.org
Epilepsy is one of the most common neurologic disorders seen in children, with the highest
incidence in the first year of life. Diagnostic accuracy can be challenging because many�…
incidence in the first year of life. Diagnostic accuracy can be challenging because many�…
Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions
LL Anderson, NL Absalom, SV Abelev, IK Low…�- …, 2019 - Wiley Online Library
Objective Cannabidiol (CBD) has been approved by the US Food and Drug Administration
(FDA) to treat intractable childhood epilepsies, such as Dravet syndrome and Lennox�…
(FDA) to treat intractable childhood epilepsies, such as Dravet syndrome and Lennox�…