Microbiome and human health: current understanding, engineering, and enabling technologies
The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the�…
inhabit various anatomical locations in the body. Accordingly, the coevolution of the�…
[HTML][HTML] A paradigm shift in translational psychiatry through rodent neuroethology
Mental disorders are a significant cause of disability worldwide. They profoundly affect
individuals' well-being and impose a substantial financial burden on societies and�…
individuals' well-being and impose a substantial financial burden on societies and�…
A Combinatorial Library of Lipid Nanoparticles for Cell Type‐Specific mRNA Delivery
GS Naidu, SB Yong, S Ramishetti…�- Advanced�…, 2023 - Wiley Online Library
Ionizable lipid‐based nanoparticles (LNPs) are the most advanced non‐viral drug delivery
systems for RNA therapeutics and vaccines. However, cell type‐specific, extrahepatic mRNA�…
systems for RNA therapeutics and vaccines. However, cell type‐specific, extrahepatic mRNA�…
Fluorescence imaging of neural activity, neurochemical dynamics, and drug-specific receptor conformation with genetically encoded sensors
C Dong, Y Zheng, K Long-Iyer…�- Annual review of�…, 2022 - annualreviews.org
Recent advances in fluorescence imaging permit large-scale recording of neural activity and
dynamics of neurochemical release with unprecedented resolution in behaving animals�…
dynamics of neurochemical release with unprecedented resolution in behaving animals�…
A red light–responsive photoswitch for deep tissue optogenetics
Y Kuwasaki, K Suzuki, G Yu, S Yamamoto…�- Nature�…, 2022 - nature.com
Red light penetrates deep into mammalian tissues and has low phototoxicity, but few
optogenetic tools that use red light have been developed. Here we present MagRed, a red�…
optogenetic tools that use red light have been developed. Here we present MagRed, a red�…
[HTML][HTML] The sensory coding of warm perception
Humans detect skin temperature changes that are perceived as warm or cool. Like humans,
mice report forepaw skin warming with perceptual thresholds of less than 1� C and do not�…
mice report forepaw skin warming with perceptual thresholds of less than 1� C and do not�…
[HTML][HTML] Optimization of tamoxifen-induced Cre activity and its effect on immune cell populations
RS Donocoff, N Teteloshvili, H Chung, R Shoulson…�- Scientific reports, 2020 - nature.com
Tamoxifen (TAM) inducible Cre recombinase system is an essential tool to study gene
function when early ablation or overexpression can cause developmental defects or�…
function when early ablation or overexpression can cause developmental defects or�…
[HTML][HTML] The functional role of extracellular matrix proteins in cancer
NV Popova, M J�cker�- Cancers, 2022 - mdpi.com
Simple Summary Extracellular matrix is a three-dimensional network of macromolecules that
provide structural and biochemical support to surrounding cells. Extracellular matrix plays a�…
provide structural and biochemical support to surrounding cells. Extracellular matrix plays a�…
Autophagy in the cancer-immunity dialogue
Autophagy is quintessential for the maintenance of cellular homeostasis in all eukaryotic
cells, explaining why both normal and malignant cells benefit from proficient autophagic�…
cells, explaining why both normal and malignant cells benefit from proficient autophagic�…
[HTML][HTML] Optogenetic manipulation and photoacoustic imaging using a near-infrared transgenic mouse model
Optogenetic manipulation and optical imaging in the near-infrared range allow non-invasive
light-control and readout of cellular and organismal processes in deep tissues in vivo. Here�…
light-control and readout of cellular and organismal processes in deep tissues in vivo. Here�…