Proteoglycans are key components of extracellular matrices, providing structural support as
well as influencing cellular behaviour in physiological and pathological processes. The�…

Glycosaminoglycans are unbranched polysaccharides composed of repeating units of
alternating uronic acids and amino sugars. Most glycosaminoglycans are covalently�…

A disintegrin and metalloproteinases (ADAMs) are a recently discovered family of proteins
that share the metalloproteinase domain with matrix metalloproteinases (MMPs). Among this�…

Increased expression of the proteoglycan, versican is strongly associated with poor outcome
for many different cancers. Depending on the cancer type, versican is expressed by either�…

Colorectal cancer originates within immunologically complex microenvironments. To date,
the benefits of immunotherapy have been modest, except in neoantigen-laden mismatch�…

Proteoglycans are a group of molecules that contain at least one glycosaminoglycan chain,
such as a heparan, dermatan, chondroitin, or keratan sulfate, covalently attached to the�…

Benign prostatic hyperplasia (BPH) is usually described as a pathological proliferation of
prostatic fibroblasts/myofibroblasts and epithelial cells. In the present study of BPH samples�…

Simple Summary Prostate cancer is a malignancy that affects a high number of men all over
the world. When indolent, prostate cancer can remain silent for years without needing�…

The complexity and diversity of proteoglycan structure means that they have a range of
functions that regulate cell behavior. Through multiple interactions of their core proteins and�…

Remodeling of ovarian follicle extracellular matrix is essential for ovulation and
vascularization of the corpus luteum (CL). Formation of the cumulus matrix around oocytes�…