The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral�…

Chronic pain is the greatest source of disability globally and claims related to chronic pain
feature in many insurance and medico-legal cases. Brain imaging (for example, functional�…

Chronic pain syndromes are often refractory to treatment and cause substantial suffering
and disability. Pain severity is often measured through subjective report, while objective�…

Human neuroimaging research has transitioned from mapping local effects to developing
predictive models of mental events that integrate information distributed across multiple�…

Chronic pain is an endemic problem involving both peripheral and brain pathophysiology.
Although biomarkers have revolutionized many areas of medicine, biomarkers for pain have�…

Importance Placebo effects reduce pain and contribute to clinical analgesia, but after
decades of research, it remains unclear whether placebo treatments mainly affect�…

Beliefs and expectations often persist despite evidence to the contrary. Here we examine
two potential mechanisms underlying such 'self-reinforcing'expectancy effects in the pain�…

Treatment outcomes are strongly influenced by expectations, as evidenced by the placebo
effect. Meta-analyses of clinical trials reveal that placebo effects are strongest in pain�…

Engaging in altruistic behaviors is costly, but it contributes to the health and well-being of the
performer of such behaviors. The present research offers a take on how this paradox can be�…

During adolescence and puberty, alterations in pain, both experimental and clinical, are
observed. In addition, adolescents undergo extensive biopsychosocial changes as they�…