Pancreatic cancer (PC) is a leading cause of cancer related mortality on a global scale. The
disease itself is associated with a dismal prognosis, partly due to its silent nature resulting in�…

Abstract RANKL/RANK/OPG system consists of three essential signaling molecules: i) the
receptor activator of nuclear factor (NF)-kB-ligand (RANKL), ii) the receptor activator of NF�…

Context: Receptor activator of nuclear factor-κB ligand (RANKL), receptor activator of
nuclear factor-κB (RANK), and osteoprotegerin (OPG) play a central role in bone remodeling�…

The discovery of the receptor activator of nuclear factor-kB (RANK)/RANK Ligand (RANKL)/
osteoprotegerin (OPG) pathway contributed to the understanding of how bone formation and�…

Purpose: This study aimed to identify a novel biomarker or a target of treatment for colorectal
cancer (CRC). Experimental Design: The expression profiles of cancer cells in 104 patients�…

BACKGROUND Late‐stage prostate cancer patients are refractory to hormone therapy and
exhibit a high propensity to develop skeletal metastasis. In this regard, the role of a novel�…

The maintenance of skeletal integrity in a healthy individual requires a balanced regulation
of the processes of bone formation, mediated by osteoblasts, and bone resorption, mediated�…

The molecular triad involving receptor activator of nuclear factor kβ (RANK)/RANK ligand
(RANKL)/osteoprotegerin cytokine system has been well implicated in several physiological�…

NK cells utilize a large array of receptors to screen their surroundings for aberrant or virus‐
infected cells. Given the vast diversity of receptors expressed on NK cells we seek to identify�…

Fibrosis is defined by excessive formation and accumulation of extracellular matrix proteins,
produced by myofibroblasts, that supersedes normal wound healing responses to injury and�…