Abstract The 2021 WHO Classification of Thoracic Tumours was published earlier this year,
with classification of lung tumors being one of the chapters. The principles remain those of�…

Simple Summary In resected lung cancer, adjuvant and neoadjuvant chemotherapy
following surgery are currently mainly based on TNM classification. With the validation and�…

The density of mitotic figures (MF) within tumor tissue is known to be highly correlated with
tumor proliferation and thus is an important marker in tumor grading. Recognition of MF by�…

Lung adenocarcinomas (LUADs) display a broad histological spectrum from low-grade
lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform�…

Fibroblasts are poorly characterised cells that variably impact tumour progression. Here, we
use single cell RNA-sequencing, multiplexed immunohistochemistry and digital cytometry�…

Recent developments in immuno-oncology demonstrate that not only cancer cells, but also
the tumor microenvironment can guide precision medicine. A comprehensive and in-depth�…

Many cancers originate from stem or progenitor cells hijacked by somatic mutations that
drive replication, exemplified by adenomatous transformation of pulmonary alveolar�…

Indolent (lepidic) and aggressive (micropapillary, solid, and poorly differentiated acinar)
histologic subtypes often coexist within a tumor tissue of lung adenocarcinoma (LUAD), but�…

Continuous revision of the histologic and stage-wise classification of lung cancer by the
World Health Organization (WHO) provides the foundation for therapeutic advances by�…

Introduction We aimed to validate the use of the novel grading system proposed by the
International Association for the Study of Lung Cancer pathology committee for prognosis�…