Cyclin D1, an important regulator of cell cycle, carries out a central role in the pathogenesis
of cancer determining uncontrolled cellular proliferation. In normal cells, Cyclin D1�…

Cyclin D1, and to a lesser extent the other D-type cyclins, is frequently deregulated in cancer
and is a biomarker of cancer phenotype and disease progression. The ability of these�…

Mammalian cells encode three D cyclins (D1, D2, and D3) that coordinately function as
allosteric regulators of cyclin-dependent kinase 4 (CDK4) and CDK6 to regulate cell cycle�…

Antibiotic resistance reduces the effectiveness of infected wound healing, and it is necessary
to develop a new strategy to promote infected wound healing without using antibiotics. Here�…

The roles of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as
core components of the machinery that drives cell cycle progression are well established�…

The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent
kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and�…

Abstract Ethnopharmacological relevance Dendrobium chrysotoxum Lindl, a well-known
traditional Chinese medicinal herb used in the treatment of gastric disease, is distinguished�…

The mammalian cell cycle is driven by a complex of cyclins and their associated cyclin-
dependent kinases (CDKs). Abnormal dysregulation of cyclin-CDK is a hallmark of cancer. D�…

Decreased expression of specific microRNAs (miRNAs) occurs in human tumors, which
suggests a function for miRNAs in tumor suppression. Herein, levels of the miR-17-5p/miR�…

Cyclin D1 overexpression is found in more than 50% of human breast cancers and causes
mammary cancer in transgenic mice. Dysregulation of cyclin D1 gene expression or function�…