Glucagon-like peptide-1 receptor agonists and dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonists in the treatment of�…
EM Muzurović, Š Volčanšek…�- Journal of�…, 2022 - journals.sagepub.com
The obesity pandemic is accompanied by increased risk of developing metabolic syndrome
(MetS) and related conditions: non-alcoholic fatty liver disease (NAFLD)/non-alcoholic�…
(MetS) and related conditions: non-alcoholic fatty liver disease (NAFLD)/non-alcoholic�…
[HTML][HTML] Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms
JE Campbell�- Molecular metabolism, 2021 - Elsevier
Background Glucose-dependent insulinotropic peptide (GIP) is one of two incretin hormones
that communicate nutrient intake with systemic metabolism. Although GIP was the first�…
that communicate nutrient intake with systemic metabolism. Although GIP was the first�…
[HTML][HTML] Proglucagon-derived peptides as therapeutics
Initially discovered as an impurity in insulin preparations, our understanding of the
hyperglycaemic hormone glucagon has evolved markedly over subsequent decades. With�…
hyperglycaemic hormone glucagon has evolved markedly over subsequent decades. With�…
Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists
LS Gasbjerg, NC Bergmann, S Stensen…�- Peptides, 2020 - Elsevier
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)
potentiate glucose-induced insulin secretion and are therefore thought to be responsible for�…
potentiate glucose-induced insulin secretion and are therefore thought to be responsible for�…
GIP and GLP-2 together improve bone turnover in humans supporting GIPR-GLP-2R co-agonists as future osteoporosis treatment
MBN Gabe, K Skov-Jeppesen, LS Gasbjerg…�- Pharmacological�…, 2022 - Elsevier
The intestinal hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-
like peptide-2 (GLP-2) are key regulators of postprandial bone turnover in humans. We�…
like peptide-2 (GLP-2) are key regulators of postprandial bone turnover in humans. We�…
Effects of endogenous GIP in patients with type 2 diabetes
S Stensen, LS Gasbjerg, LL Krogh…�- European Journal of�…, 2021 - academic.oup.com
Objective The insulinotropic effect of exogenous, intravenously infused glucose-dependent
insulinotropic polypeptide (GIP) is impaired in patients with type 2 diabetes. We evaluated�…
insulinotropic polypeptide (GIP) is impaired in patients with type 2 diabetes. We evaluated�…
[HTML][HTML] Irisin and incretin hormones: Similarities, differences, and implications in type 2 diabetes and obesity
Incretins are gut hormones that potentiate glucose-stimulated insulin secretion (GSIS) after
meals. Glucagon-like peptide-1 (GLP-1) is the most investigated incretin hormone�…
meals. Glucagon-like peptide-1 (GLP-1) is the most investigated incretin hormone�…
[HTML][HTML] Glucagon-like peptide-2 ameliorates age-associated bone loss and gut barrier dysfunction in senescence-accelerated mouse prone 6 mice
YM Huang, B Xu, Z Kuai, YT He, Y Lu, JP Shen, KF Wu…�- Gerontology, 2023 - karger.com
Introduction: Senile osteoporosis is one of the most common age-related diseases
worldwide. Glucagon like peptide-2 (GLP-2), a naturally occurring gastrointestinal peptide�…
worldwide. Glucagon like peptide-2 (GLP-2), a naturally occurring gastrointestinal peptide�…
GIP affects hepatic fat and brown adipose tissue thermogenesis but not white adipose tissue transcriptome in type 1 diabetes
SMN Heimb�rger, B Hoe, CN Nielsen…�- The Journal of�…, 2022 - academic.oup.com
Context Glucose-dependent insulinotropic polypeptide (GIP) has been proposed to exert
insulin-independent effects on lipid and bone metabolism. Objective We investigated the�…
insulin-independent effects on lipid and bone metabolism. Objective We investigated the�…
[HTML][HTML] Alliances of the gut and bone axis
MS Hansen, M Frost�- Seminars in Cell & Developmental Biology, 2022 - Elsevier
Gut hormones secreted from enteroendocrine cells following nutrient ingestion modulate
metabolic processes including glucose homeostasis and food intake, and several of these�…
metabolic processes including glucose homeostasis and food intake, and several of these�…