[HTML][HTML] GABAergic interneurons in the neocortex: from cellular properties to circuits
Cortical networks are composed of glutamatergic excitatory projection neurons and local
GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics�…
GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics�…
Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders
VS Sohal, JLR Rubenstein�- Molecular psychiatry, 2019 - nature.com
Abstract In 2003 Rubenstein and Merzenich hypothesized that some forms of Autism (ASD)
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the�…
might be caused by a reduction in signal-to-noise in key neural circuits, which could be the�…
[HTML][HTML] Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level
The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain�…
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain�…
[HTML][HTML] Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology
Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the
molecular and cellular mechanisms underlying cognitive impairment remain poorly�…
molecular and cellular mechanisms underlying cognitive impairment remain poorly�…
Optogenetics: 10 years of microbial opsins in neuroscience
K Deisseroth�- Nature neuroscience, 2015 - nature.com
Over the past 10 years, the development and convergence of microbial opsin engineering,
modular genetic methods for cell-type targeting and optical strategies for guiding light�…
modular genetic methods for cell-type targeting and optical strategies for guiding light�…
Mechanisms of gamma oscillations
Gamma rhythms are commonly observed in many brain regions during both waking and
sleep states, yet their functions and mechanisms remain a matter of debate. Here we review�…
sleep states, yet their functions and mechanisms remain a matter of debate. Here we review�…
[HTML][HTML] Shaping functional architecture by oscillatory alpha activity: gating by inhibition
O Jensen, A Mazaheri�- Frontiers in human neuroscience, 2010 - frontiersin.org
In order to understand the working brain as a network, it is essential to identify the
mechanisms by which information is gated between regions. We here propose that�…
mechanisms by which information is gated between regions. We here propose that�…
Neocortical excitation/inhibition balance in information processing and social dysfunction
Severe behavioural deficits in psychiatric diseases such as autism and schizophrenia have
been hypothesized to arise from elevations in the cellular balance of excitation and�…
been hypothesized to arise from elevations in the cellular balance of excitation and�…
[HTML][HTML] The theta-gamma neural code
JE Lisman, O Jensen�- Neuron, 2013 - cell.com
Theta and gamma frequency oscillations occur in the same brain regions and interact with
each other, a process called cross-frequency coupling. Here, we review evidence for the�…
each other, a process called cross-frequency coupling. Here, we review evidence for the�…
[HTML][HTML] Natural neural projection dynamics underlying social behavior
Social interaction is a complex behavior essential for many species and is impaired in major
neuropsychiatric disorders. Pharmacological studies have implicated certain�…
neuropsychiatric disorders. Pharmacological studies have implicated certain�…