Nanomedicines improve drug bioavailability, the dose–response relationship, targeting
ability, efficacy and safety compared to conventional freely administered drugs�…

The propensity of the hepatic macrophages (Kupffer cells) to rapidly intercept particulate
materials from the blood has been frustrating in redirecting intravenously injected�…

A growing body of multiscale biomechanical studies has been proposed to highlight the
mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level�…

Gene therapy is poised to revolutionize modern medicine, with seemingly unlimited potential
for treating and curing genetic disorders. For otherwise incurable indications, including most�…

Endothelial cells play critical roles in circulatory homeostasis and are also the gateway to
the major organs of the body. Dysfunction, injury, and gene expression profiles of these cells�…

Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among
patients with colorectal cancer (CRC). Although immunotherapy has demonstrated�…

The main component of blood and lymphatic vessels is the endothelium covering their
luminal surface. It plays a significant role in many cardiovascular diseases. Tremendous�…

Intracellular gap (iGap) formation in liver sinusoidal endothelial cells (LSECs) is caused by
the destruction of fenestrae and appears under pathological conditions; nevertheless, their�…

Liver fibrosis is a process of over‐extracellular matrix (ECM) aggregation and angiogenesis,
which develops into cirrhosis and hepatocellular carcinoma (HCC). With the increasing�…

Non-alcoholic fatty liver disease (NAFLD) and its progressive form non-alcoholic
steatohepatitis (NASH) have presented a major and common health concern worldwide due�…