Abstract Systems neuroscience approaches with a focus on large-scale brain organization
and network analysis are advancing foundational knowledge of how cognitive control�…

The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities�…

The orbitofrontal cortex in primates including humans is the key brain area in emotion, and
in the representation of reward value and in non-reward, that is not obtaining an expected�…

Anxiety is experienced in response to threats that are distal or uncertain, involving changes
in one's subjective state, autonomic responses, and behavior. Defensive and physiologic�…

During evolution, the prefrontal region grew in size relative to the rest of the cortex. It
reached its largest extent in the human brain, where it constitutes 30% of the total cortical�…

The orbitofrontal cortex and amygdala are involved in emotion and in motivation, but the
relationship between these functions performed by these brain structures is not clear. To�…

The higher-order theory (HOT) of consciousness has often been misunderstood by critics.
Here, we clarify its position on several issues, and distinguish it from other views, such as�…

Although neuroscience has made remarkable progress in understanding the involvement of
prefrontal cortex (PFC) in human memory, the necessity of dorsolateral PFC (dlPFC) for key�…

An alternative parcellation of the orbitofrontal cortex is described for the automated
anatomical labeling atlas of Tzourio-Mazoyer et al.(2002)(Automated anatomical labeling of�…

The human cerebral cortex is vastly expanded relative to other primates and
disproportionately occupied by distributed association regions. Here we offer a hypothesis�…