Brain ischemia affects all ages, from neonates to the elderly population, and is a leading
cause of mortality and morbidity. Multiple preclinical rodent models involving different ages�…

Cerebral ischemia remains a leading cause of mortality worldwide. Although the incidence
of death has decreased over the years, surviving patients may suffer from long-term�…

Astragaloside IV (AST) as the main active ingredient of Astragalus membranaceus. Clinical
and laboratory-based studies have demonstrated the effects of AST on cerebral protection�…

We review emerging preclinical and clinical evidence regarding brain-derived neurotrophic
factor (BDNF) protein, genotype, and DNA methylation (DNAm) as biomarkers of outcomes�…

Hippocampal injury and cognitive impairments are common after cardiac arrest and stroke
and do not have an effective intervention despite much effort. Therefore, we developed a�…

Ischemic stroke is a leading cause of death worldwide and clinical data suggest that children
may recover from stroke better than adults; however, supporting experimental data are�…

Hippocampal cell death and cognitive dysfunction are common following global cerebral
ischemia across all ages, including children. Most research has focused on preventing�…

To elucidate the mechanisms of memory impairment after chronic neonatal intermittent
hypoxia (IH), we employed a mice model of severe IH administered at postnatal days 3 to 7�…

Forebrain ischemia induces delayed, selective neuronal death in hippocampal CA1. It has
been established that BDNF (brain-derived neurotrophic factor) is an important factor in�…

Neurological symptoms following cerebellar stroke can range from motor to cognitive-
affective impairments. Topographic imaging studies from patients with lesions confined to�…