Over one-third of patients with temporal lobe epilepsy are refractory to medication. In
addition, anti-epileptic drugs often exacerbate cognitive comorbidities. Neuromodulation is�…

Although it is accepted that idiopathic generalized epilepsy (IGE) is strongly, if not
exclusively, influenced by genetic factors, there is little consensus on what those genetic�…

The aim was to investigate the long-term effects of a single episode of immature Status
Epilepticus (SE) on the excitability of the septal and temporal hippocampus in vitro, by�…

Objective Cognitive impairment often impacts quality of life in epilepsy even if seizures are
controlled. Word‐finding difficulty is particularly prevalent and often attributed to etiological�…

nociferous influence of interictal discharges on memory | Brain | Oxford Academic Skip to Main
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Focal forms of epilepsy can result from a wide range of insults and can vary from focal
symptoms to generalized convulsions. Most drugs that have been developed for epilepsy�…

Abstract Purpose of Review Our purpose is to review evidence relating to the concept that
interictal epileptiform discharges (IEDs) impair brain performance. Recent Findings�…

Antibodies (Ab's) to glutamate receptors, directed specifically against AMPA receptors
subunit 3 peptide B (ie GluR3 amino acids 372–395), named GluR3B Ab's, can by�…

Investigations of interictal epileptiform spikes and seizures have played a central role in the
study of epilepsy. The background EEG activity, however, has received less attention. In this�…

Autism spectrum disorder (ASD) is a common comorbidity of epilepsy and seizures and/or
epileptiform activity are observed in a significant proportion of ASD patients. Current�…