ETHNOPHARMACOLOGICAL RELEVANCE: Orchis mascula tuber is used in many
polyherbal formulations as a nerve tonic in India. AIM OF THE STUDY: In the present study�…

Evidence from animal models and patient data indicates that febrile status epilepticus (FSE)
in early development can result in permanently diminished cognitive abilities. To understand�…

The purpose of this study was to examine how sleep impacts memory function in temporal
lobe epilepsy (TLE). Patients with TLE (n= 7) and control subjects (n= 9) underwent training�…

One of the most common and serious co-morbidities in patients with epilepsy is cognitive
impairment. While early-life seizures are considered a major cause for cognitive impairment�…

Working memory (WM) deficits are pervasive co-morbidities of epilepsy. Although the
pathophysiological mechanisms underpinning these impairments remain elusive, it is�…

Abstract Objective Interictal epileptiform discharges (IEDs) were shown to be associated with
cognitive impairment in persons with epilepsy. Previous studies indicated that IED rate�…

Dravet Syndrome (DS) is a genetic, infantile-onset epilepsy with refractory seizures and
severe cognitive impairment. While network level pathophysiology is poorly understood�…

Objective Patients with temporal lobe epilepsy often display cognitive comorbidity with
recurrent seizures. However, the cellular mechanisms underlying the impairment of�…

There is a substantial body of evidence that spontaneous recurrent seizures occur in a
subset of patients with Alzheimer disease (AD), especially the familial forms that have an�…

Objective. We aim to increase the number of neural spikes that can be detected in a single
channel extracellular neural recording. Approach. We propose a pre-emphasis method�…