There has been a major emphasis on defining the role of seizures in the causation of
cognitive impairments like memory deficits in epilepsy. Here we focus on an alternative�…

How the development and function of neural circuits governing learning and memory are
affected by insults in early life remains poorly understood. The goal of this study was to�…

Interictal spikes are brief paroxysmal electrographic discharges observed between
spontaneous recurrent seizures in epileptic patients. The relationship between interictal�…

Seizures in patients with Alzheimer's disease (AD) have been examined by many
investigators over the last several decades, and there are diverse opinions about their�…

Objective Non‐rapid eye movement (NREM) sleep is supposed to play a key role in long‐
term memory consolidation transferring information from hippocampus to neocortex�…

Dravet syndrome (DS) is a childhood disorder associated with loss-of-function mutations in
SCN1A and is characterized by frequent seizures and severe cognitive impairment. Animal�…

Glutamate is the major excitatory neurotransmitter of the Central Nervous System (CNS),
and it is crucially needed for numerous key neuronal functions. Yet, excess glutamate�…

Most research on focal epilepsy focuses on mechanisms of seizure generation in the
primary epileptic focus (EF). However, neurological deficits that are not directly linked to�…

Cognitive comorbidities are more frequent in children with epilepsy than in the general
population. The cognitive function of children with epilepsy should be appropriately�…

Epileptic encephalopathies are a group of diseases in which epileptic activity itself
contributes to severe cognitive and behavioral impairments above and beyond what might�…