Abstract See Kleen and Kirsch (doi: 10.1093/awx178) for a scientific commentary on this
article. Cognitive deficits are common among epilepsy patients. In these patients, interictal�…

It has been suggested that neuronal hyperexcitability contributes to Alzheimer's disease
(AD), so we asked how hyperexcitability develops in a common mouse model of β-amyloid�…

Memory complaints and deficits are common in patients with epilepsy, especially temporal
lobe epilepsy (TLE), where memory-related brain structures are directly involved in the�…

Objective Reducing levels of the microtubule‐associated protein tau has shown promise as
a potential treatment strategy for diseases with secondary epileptic features such as�…

Epilepsy is increasingly recognized as a disease that reaches well beyond seizures.
Cognitive and psychiatric impairment affect half of all epilepsy patients, and to date there are�…

Epilepsy is a complex disorder, which involves much more than seizures, encompassing a
range of associated comorbid health conditions that can have significant health and quality�…

Epilepsy is often associated with cognitive and behavioral impairments that can have
profound impact on the quality of life of patients. Although the mechanisms of cognitive�…

Objective Develop a high-performing algorithm to detect mesial temporal lobe (mTL)
epileptiform discharges on intracranial electrode recordings. Methods An epileptologist�…

Objectives Interictal epileptiform discharges (IED s) have been linked to memory impairment,
but the spatial and temporal dynamics of this relationship remain elusive. In the present�…

A recent article by Farrell et al. characterizes the phenomenon, mechanisms, and treatment
of a local and severe hypoperfusion/hypoxia event that occurs in brain regions following a�…