The population of aged individuals is increasing worldwide and this has significant health
and socio-economic implications. Clinical and experimental studies on aging have�…

Iron is indispensable for normal body functions across species because of its critical roles in
red blood cell function and many essential proteins and enzymes required for numerous�…

Iron is the most abundant transition metal within the brain, and is vital for a number of
cellular processes including neurotransmitter synthesis, myelination of neurons, and�…

Recent and accumulating work in experimental animal models and humans shows that diet
has a much more pervasive and prominent role than previously thought in modulating�…

Dietary interventions can ameliorate age-related neurological decline. Decades of research
of in vitro studies, animal models, and clinical trials support their ability and efficacy to�…

Research into the biology of aging seeks to understand the basic mechanisms of aging, with
the goal of extending the period of life spent free from chronic disease and disability. Aging�…

Aging is the biological process of declining physiologic function associated with increasing
mortality rate during advancing age. Humans and higher nonhuman primates exhibit�…

Background Globally improved life expectancy has led to a significant increase in the
incidence of Parkinson's disease (PD). It is widely thought that dietary factors are crucial�…

Background Caloric restriction (CR) can increase longevity in rodents and improve memory
function in humans. α-Lipoic acid (LA) has been shown to improve memory function in rats�…

Abstract Alzheimer's (AD), Huntington's (HD), and Parkinson's (PD) disease are age-related
neurodegenerative disorders characterized by progressive neuronal cell death. Although�…