Angiogenesis is the outgrowth of new blood vessels from the preexistent vasculature. In
1971, Folkman hypothesized that solid tumors are dependent on angiogenesis for sustained�…

Brain tumors—particularly glioblastoma multiforme—pose an important public health
problem in the United States. Despite surgical and medical advances, the prognosis for�…

Abstract PTK787/ZK 222584 (1-[4-chloroanilino]-4-[4-pyridylmethyl] phthalazine succinate)
is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases�…

The inhibition of new blood vessel formation (angiogenesis) is an effective means of limiting
both the size and metastasis of solid tumors. The leading anti-angiogenic compound, TNP�…

Background Profound hearing loss is a serious complication of neurofibromatosis type 2, a
genetic condition associated with bilateral vestibular schwannomas, benign tumors that�…

Research studies suggest that tumor-related angiogenesis contributes to the phenotype of
malignant gliomas. We assessed the effect of local delivery of the angiogenesis inhibitor�…

Targeting angiogenesis, the formation of blood vessels, is an important modality for cancer
therapy. TNP-470, a fumagillin analog, is among the most potent and broad-spectrum�…

TNP-470, an analogue of fumagillin, has been shown to inhibit angiogenesis in vitro and in
vivo. In 1992, TNP-470 entered clinical development for cancer as an anti-angiogenic agent�…

BACKGROUND Identification of the prognosis of patients with gliomas is important for
selecting and evaluating the effectiveness of treatment. The aim of this study was to evaluate�…

Human malignant gliomas are among the most malignant and most intensely vascularized
solid tumors. Angiostatin, an internal fragment of plasminogen, was recently discovered as�…