Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches
J Beermann, MT Piccoli, J Viereck…�- Physiological�…, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear�…
coding transcripts with unknown function. There are several types of non-coding linear�…
The functions and unique features of long intergenic non-coding RNA
JD Ransohoff, Y Wei, PA Khavari�- Nature reviews Molecular cell�…, 2018 - nature.com
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin�…
them from mRNA-encoding genes and exercise functions such as remodelling chromatin�…
[HTML][HTML] The noncoding RNA revolution—trashing old rules to forge new ones
TR Cech, JA Steitz�- Cell, 2014 - cell.com
Noncoding RNAs (ncRNAs) accomplish a remarkable variety of biological functions. They
regulate gene expression at the levels of transcription, RNA processing, and translation�…
regulate gene expression at the levels of transcription, RNA processing, and translation�…
[HTML][HTML] lincRNAs: genomics, evolution, and mechanisms
Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in
mammalian genomes and might play widespread roles in gene regulation and other cellular�…
mammalian genomes and might play widespread roles in gene regulation and other cellular�…
[HTML][HTML] The multidimensional mechanisms of long noncoding RNA function
A major shift in our understanding of genome regulation has emerged recently. It is now
apparent that the majority of cellular transcripts do not code for proteins, and many of them�…
apparent that the majority of cellular transcripts do not code for proteins, and many of them�…
The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression
The human genome contains many thousands of long noncoding RNAs (lncRNAs). While
several studies have demonstrated compelling biological and disease roles for individual�…
several studies have demonstrated compelling biological and disease roles for individual�…
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
RC Lee, RL Feinbaum, V Ambros�- cell, 1993 - cell.com
Summary h-4 is essential for the normal temporal control of diverse postembryonic
developmental events in C. elegans./in-4 acts by negatively regulating the level of LIN-14�…
developmental events in C. elegans./in-4 acts by negatively regulating the level of LIN-14�…
Modular regulatory principles of large non-coding RNAs
It is clear that RNA has a diverse set of functions and is more than just a messenger between
gene and protein. The mammalian genome is extensively transcribed, giving rise to�…
gene and protein. The mammalian genome is extensively transcribed, giving rise to�…
The multilayered complexity of ceRNA crosstalk and competition
Y Tay, J Rinn, PP Pandolfi�- Nature, 2014 - nature.com
Recent reports have described an intricate interplay among diverse RNA species, including
protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs�…
protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs�…
Gene regulation in time and space during X-chromosome inactivation
A Loda, S Collombet, E Heard�- Nature Reviews Molecular Cell Biology, 2022 - nature.com
X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for�…
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for�…