The p16INK4A (hereafter p16) tumor suppressor is encoded by the INK4A/ARF locus which
is among the most commonly dysregulated sequences in human cancer. By inhibiting cyclin�…

Oncology Book of 2011, British Medical Association's Medical Book Awards Awarded first
prize in the Oncology category at the 2011 BMA Medical Book Awards, Monoclonal Antibody�…

Herein we used single‐cell observation methods to gain insight into the roles of p16INK4A
and p21WAF1 (hereafter p16 and p21) in replicative senescence and ionizing radiation�…

Abbreviations: HDS, high density survival; CFA, colonyforming ability; CaMKII,
calcium/calmodulin-dependent protein kinase II; PI3K, phosphatidylinositol 3-kinase; PBS�…

Induction of the p21WAF1 protein (hereafter called p21) following genotoxic stress is known
to inhibit proliferating cell nuclear antigen (PCNA)‐dependent DNA repair, downregulate�…

The need to monitor cancer therapy-induced cellular and tissue changes using noninvasive
imaging techniques continues to stimulate both basic and clinical research. Monitoring�…

Cancer therapy has witnessed major advances in the last few decades. However, the
conventional therapies have a narrow therapeutic application, and the responses produced�…

Our genetic material is constantly damaged by internal sources such as reactive oxygen
species and external sources such as ionizing radiation and sunlight. However, we seldom�…

In this chapter, the radiation biology of targeted radiotherapy (TRT) will be discussed. In
particular, the chapter will focus on how our improved understanding of the cellular DNA�…

Radiation therapy (XRT) continues to be an important component in the management of
many cancer patients. The dose delivered to a tumor is calculated on the basis of the�…