[HTML][HTML] Butyrate producers,“The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics

V Singh, GD Lee, HW Son, H Koh, ES Kim…�- Frontiers in�…, 2023 - frontiersin.org
Gut-microbial butyrate is a short-chain fatty acid (SCFA) of significant physiological
importance than the other major SCFAs (acetate and propionate). Most butyrate producers�…

Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease

B Jia, Y Zou, X Han, JW Bae, CO Jeon�- Trends in Microbiology, 2023 - cell.com
Cardiovascular disease (CVD) is a health problem worldwide, and elevated cholesterol
levels are a key risk factor for the disease. Dysbiotic gut microbiota has been shown to be�…

Clostridium butyricum and its derived extracellular vesicles modulate gut homeostasis and ameliorate acute experimental colitis

L Ma, Q Shen, W Lyu, L Lv, W Wang, M Yu…�- Microbiology�…, 2022 - Am Soc Microbiol
Microbiological treatments are expected to have a role in the future management of
inflammatory bowel disease (IBD). Clostridium butyricum (C. butyricum) is a probiotic�…

[HTML][HTML] Gut liver brain axis in diseases: the implications for therapeutic interventions

M Yan, S Man, B Sun, L Ma, L Guo, L Huang…�- Signal Transduction and�…, 2023 - nature.com
Gut-liver-brain axis is a three-way highway of information interaction system among the
gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough�…

[HTML][HTML] DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

P Qu, O Rom, K Li, L Jia, X Gao, Z Liu, S Ding, M Zhao…�- Cell metabolism, 2023 - cell.com
Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy
approved. A major hurdle in NASH drug development is the poor translatability of preclinical�…

The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management

A Nabavi-Rad, A Sadeghi, H Asadzadeh Aghdaei…�- Gut�…, 2022 - Taylor & Francis
As Helicobacter pylori management has become more challenging and less efficient over
the last decade, the interest in innovative interventions is growing by the day. Probiotic co�…

Metabolite profiling of human‐originated Lachnospiraceae at the strain level

R Abdugheni, WZ Wang, YJ Wang, MX Du, FL Liu…�- Imeta, 2022 - Wiley Online Library
The human gastrointestinal (GI) tract harbors diverse microbes, and the family
Lachnospiraceae is one of the most abundant and widely occurring bacterial groups in the�…

[HTML][HTML] Crosstalk between the gut microbiome and colonic motility in chronic constipation: potential mechanisms and microbiota modulation

R Pan, L Wang, X Xu, Y Chen, H Wang, G Wang…�- Nutrients, 2022 - mdpi.com
Chronic constipation (CC) is a highly prevalent and burdensome gastrointestinal disorder.
Accumulating evidence highlights the link between imbalances in the gut microbiome and�…

Role of the gut microbiota and its metabolites in tumorigenesis or development of colorectal cancer

R Qu, Y Zhang, Y Ma, X Zhou, L Sun, C Jiang…�- Advanced�…, 2023 - Wiley Online Library
Colorectal cancer (CRC) is the most common cancer of the digestive system with high
mortality and morbidity rates. Gut microbiota is found in the intestines, especially the�…

An engineered butyrate-derived polymer nanoplatform as a mucosa-healing enhancer potentiates the therapeutic effect of magnolol in inflammatory bowel disease

X Fan, Z Zhang, W Gao, Q Pan, K Luo, B He, Y Pu�- ACS nano, 2023 - ACS Publications
Colonic epithelial damage and dysregulated immune response are crucial factors in the
progression and exacerbation of inflammatory bowel disease (IBD). Nanoenabled targeted�…