Its semi-allogeneic nature renders the conceptus vulnerable to attack by the maternal
immune system. Several protective mechanisms operate during gestation to correct the�…

Among mammalian species, human reproduction has 2 outstanding features. The human
hemochorial placentation is characterized by a very deep endovascular trophoblast invasion�…

Discrimination of self from non-self is fundamental to a wide range of immunological
processes. During pregnancy, the mother does not recognize the placenta as�…

Exosomes are a subset of extracellular vesicles with an average diameter of~ 100nm.
Exosomes are released by all cells through an endosome-dependent pathway and carry�…

Preterm birth (PTB) is the leading cause of death in children under five, yet comprehensive
studies are hindered by its multiple complex etiologies. Epidemiological associations�…

Successful pregnancy is a unique situation requires the maternal immune system to
recognize and tolerate a semi‐identical fetus and allow normal invasion of trophoblast cells�…

The human conceptus is a semi-allograft, which is antigenically foreign to the mother.
Hence, the implantation process needs mechanisms to prevent allograft rejection during�…

Pregnancy is a common immunization event, but the molecular mechanisms and
immunological consequences provoked by pregnancy remain largely unknown. We used�…

Breast cancer during pregnancy (PrBC) is a rare tumor with only a little information on its
immune landscape. Here, we sought to characterize the cellular composition of the tumor�…

Pregnancy requires the process of maternal immune tolerance to semi-allogeneic embryos.
In contrast, an overreactive maternal immune system to embryo-specific antigens is likely to�…