Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana
MC Thigpen, PM Kebaabetswe…�- New England journal�…, 2012 - Mass Medical Soc
Background Preexposure prophylaxis with antiretroviral agents has been shown to reduce
the transmission of human immunodeficiency virus (HIV) among men who have sex with�…
the transmission of human immunodeficiency virus (HIV) among men who have sex with�…
Development of antiretroviral drug resistance
MA Wainberg, GJ Zaharatos…�- New England Journal of�…, 2011 - Mass Medical Soc
Analysis of HIV drug resistance has identified sites on HIV target genes that convey
resistance to particular classes of agents. These data may be especially important in�…
resistance to particular classes of agents. These data may be especially important in�…
Low-abundance drug-resistant HIV-1 variants in antiretroviral drug-naive individuals: a systematic review of detection methods, prevalence, and clinical impact
Background The presence of high-abundance drug-resistant HIV-1 jeopardizes success of
antiretroviral therapy (ART). Despite numerous investigations, the clinical impact of low�…
antiretroviral therapy (ART). Despite numerous investigations, the clinical impact of low�…
Risk of drug resistance among persons acquiring HIV within a randomized clinical trial of single-or dual-agent preexposure prophylaxis
Abstract Background. Preexposure prophylaxis (PrEP) with emtricitabine plus tenofovir
disoproxil fumarate (FTC/TDF) or TDF alone reduces the risk of human immunodeficiency�…
disoproxil fumarate (FTC/TDF) or TDF alone reduces the risk of human immunodeficiency�…
Are subtype differences important in HIV drug resistance?
RJ Lessells, DK Katzenstein, T De Oliveira�- Current opinion in virology, 2012 - Elsevier
The diversity of human immunodeficiency virus type 1 (HIV-1) has given rise to multiple
subtypes and recombinant strains. The majority of research into antiretroviral agents and�…
subtypes and recombinant strains. The majority of research into antiretroviral agents and�…
[HTML][HTML] Virologic failure of protease inhibitor-based second-line antiretroviral therapy without resistance in a large HIV treatment program in South Africa
JH Levison, C Orrell, S Gallien, DR Kuritzkes, N Fu…�- PloS one, 2012 - journals.plos.org
Background We investigated the prevalence of wild-type virus (no major drug resistance)
and drug resistance mutations at second-line antiretroviral treatment (ART) failure in a large�…
and drug resistance mutations at second-line antiretroviral treatment (ART) failure in a large�…
Impact of pretreatment low-abundance HIV-1 drug resistance on virological failure after 1 year of antiretroviral therapy in China
M Li, C Song, J Hu, A Dong, R Kang…�- Journal of�…, 2023 - academic.oup.com
Objectives To assess the impact of pretreatment low-abundance HIV drug-resistant variants
(LA-DRVs) on virological outcomes among ART-naive HIV-1-infected Chinese people who�…
(LA-DRVs) on virological outcomes among ART-naive HIV-1-infected Chinese people who�…
Deep sequencing of HIV: clinical and research applications
SB Chabria, S Gupta, MJ Kozal�- Annual review of genomics�…, 2014 - annualreviews.org
Human immunodeficiency virus (HIV) exhibits remarkable diversity in its genomic makeup
and exists in any given individual as a complex distribution of closely related but�…
and exists in any given individual as a complex distribution of closely related but�…
HIV drug resistance levels in adults failing first‐line antiretroviral therapy in an urban and a rural setting in S outh A frica
Objectives Urban and rural HIV treatment programmes face different challenges in the long‐
term management of patients. There are few studies comparing drug resistance profiles in�…
term management of patients. There are few studies comparing drug resistance profiles in�…
[HTML][HTML] A template-dependent dislocation mechanism potentiates K65R reverse transcriptase mutation development in subtype C variants of HIV-1
D Coutsinos, CF Invernizzi, D Moisi, M Oliveira…�- PloS one, 2011 - journals.plos.org
Numerous studies have suggested that the K65R reverse transcriptase (RT) mutation
develops more readily in subtype C than subtype B HIV-1. We recently showed that this�…
develops more readily in subtype C than subtype B HIV-1. We recently showed that this�…