The epithelial–mesenchymal transition (EMT) is an essential event during cell development,
in which epithelial cells acquire mesenchymal fibroblast-like features including reduced�…

Fibrosis — A Common Pathway to Organ Injury and Failure | New England Journal of Medicine
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Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and�…

Fibrosis is defined by the overgrowth, hardening, and/or scarring of various tissues and is
attributed to excess deposition of extracellular matrix components including collagen�…

Centella asiatica (also known as Centella asiatica (L.) Urb. or Gotu kola) is a traditional
Chinese medicine with extensive medicinal value, which is commonly used in Southeast�…

Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the�…

The crucial role played by the myofibroblast in wound healing and pathological organ
remodeling is well established; the general mechanisms of extracellular matrix synthesis�…

The discovery of the myofibroblast has opened new perspectives for the comprehension of
the biological mechanisms involved in wound healing and fibrotic diseases. In recent years�…

Pulmonary fibrosis is a highly heterogeneous and lethal pathological process with limited
therapeutic options. Although research on the pathogenesis of pulmonary fibrosis has�…

It is generally accepted that fibroblast-to-myofibroblast differentiation represents a key event
during wound healing and tissue repair. The high contractile force generated by�…