Locus coeruleus: a new look at the blue spot
The locus coeruleus (LC), or 'blue spot', is a small nucleus located deep in the brainstem
that provides the far-reaching noradrenergic neurotransmitter system of the brain. This�…
that provides the far-reaching noradrenergic neurotransmitter system of the brain. This�…
A conceptual framework for astrocyte function
The participation of astrocytes in brain computation was hypothesized in 1992, coinciding
with the discovery that these cells display a form of intracellular Ca2+ signaling sensitive to�…
with the discovery that these cells display a form of intracellular Ca2+ signaling sensitive to�…
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline
Several autopsy studies recognize the locus coeruleus (LC) as the initial site of
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU�…
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU�…
Questions and controversies in the study of time-varying functional connectivity in resting fMRI
The brain is a complex, multiscale dynamical system composed of many interacting regions.
Knowledge of the spatiotemporal organization of these interactions is critical for establishing�…
Knowledge of the spatiotemporal organization of these interactions is critical for establishing�…
[HTML][HTML] Mechanisms of memory under stress
It is well established that stress has a major impact on memory, driven by the concerted
action of various stress mediators on the brain. Recent years, however, have seen�…
action of various stress mediators on the brain. Recent years, however, have seen�…
[HTML][HTML] Why is everyone talking about brain state?
The rapid and coordinated propagation of neural activity across the brain provides the
foundation for complex behavior and cognition. Technical advances across neuroscience�…
foundation for complex behavior and cognition. Technical advances across neuroscience�…
Fast-specific fluorescent probes to visualize norepinephrine signaling pathways and its flux in the epileptic mice brain
H Yan, Y Wang, F Huo, C Yin�- Journal of the American Chemical�…, 2023 - ACS Publications
Norepinephrine (NE) is synthesized in the locus coeruleus and widely projected throughout
the brain and spinal cord. It regulates various actions and consciousness linked to a variety�…
the brain and spinal cord. It regulates various actions and consciousness linked to a variety�…
Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics
Decades of neurobiological research have disclosed the diverse manners in which the
response properties of neurons are dynamically modulated to support adaptive cognitive�…
response properties of neurons are dynamically modulated to support adaptive cognitive�…
Functional brain networks reflect spatial and temporal autocorrelation
High-throughput experimental methods in neuroscience have led to an explosion of
techniques for measuring complex interactions and multi-dimensional patterns. However�…
techniques for measuring complex interactions and multi-dimensional patterns. However�…
[HTML][HTML] The role of the salience network in cognitive and affective deficits
J Schimmelpfennig, J Topczewski…�- Frontiers in human�…, 2023 - frontiersin.org
Analysis and interpretation of studies on cognitive and affective dysregulation often draw
upon the network paradigm, especially the Triple Network Model, which consists of the�…
upon the network paradigm, especially the Triple Network Model, which consists of the�…