Epilepsy is a chronic neurological disease characterized by an enduring propensity for
generation of seizures. The pathogenic processes of seizure generation and recurrence are�…

Epilepsy is the third most common chronic brain disorder, and is characterized by an
enduring predisposition to generate seizures. Despite progress in pharmacological and�…

Reactive astrocytes play an important role in neurological diseases, but their molecular and
functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal�…

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed�…

Over the past two decades it became evident that the immune system plays a central role in
modulating learning, memory and neural plasticity. Under normal quiescent conditions�…

Our body handles tissue damage by activating the immune system in response to
intracellular molecules released by injured tissues [damage-associated molecular patterns�…

A key question in immunology concerns how sterile injury activates innate immunity to
mediate damaging inflammation in the absence of foreign invaders. The discovery that�…

Epilepsy affects~ 65 million people worldwide. First-line treatment options include> 20
antiseizure medications, but seizure control is not achieved in approximately one-third of�…

Increasing evidence corroborates the fundamental role of neuroinflammation in the
development of epilepsy. Proinflammatory cytokines (PICs) are crucial contributors to the�…

Epilepsy is characterized by recurrent spontaneous seizures due to hyperexcitability and
hypersynchrony of brain neurons. Current theories of pathophysiology stress neuronal�…