Preterm birth is an increasing worldwide problem. Prematurity is the second most common
cause of death in children under 5 years of age. It is associated with a higher risk of several�…

Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor
APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by�…

The predicted protein encoded by the APJ gene discovered in 1993 was originally classified
as a class AG protein-coupled orphan receptor but was subsequently paired with a novel�…

Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein-
coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have�…

Excess iron accumulation and cardiac oxidative stress have been shown as important
mediators of cardiac hypertrophy, whereas it remains largely elusive about the occurrence of�…

Hyperglycaemia-mediated oxidative stress plays an imperative role in the progression of
diabetic nephropathy. NF-kB is an important transcription factor in eukaryotes which�…

Objective This study aimed to evaluate the effects of royal jelly (RJ) on serum biochemical
alterations and oxidative stress status in liver and pancreas of streptozotocin (STZ)-induced�…

Background Sarcolipin and uncoupling protein 3 (UCP3) mediate muscle-based non-
shivering thermogenesis (NST) to improve metabolic homeostasis. The impacts of maternal�…

Pregnancy is a dynamic and precisely organized process during which one or more baby
develops. Embryonic development relies on the formation of the placenta, allowing nutrient�…

Hepatic fibrosis is the consequence of an unresolved wound healing process in response to
chronic liver injury and involves multiple cell types and molecular mechanisms. The hepatic�…