[HTML][HTML] Pathogenic mechanisms underlying idiopathic pulmonary fibrosis
The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in�…
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in�…
[HTML][HTML] Targeting fibrosis: Mechanisms and clinical trials
M Zhao, L Wang, M Wang, S Zhou, Y Lu…�- Signal transduction and�…, 2022 - nature.com
Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop�…
dysregulated wound and connective tissue repair response. Multiple organs can develop�…
Spectrum of fibrotic lung diseases
M Wijsenbeek, V Cottin�- New England Journal of Medicine, 2020 - Mass Medical Soc
Pulmonary Fibrotic Diseases This review covers fibrotic pulmonary diseases. Although
idiopathic pulmonary fibrosis is very common, the review focuses mainly on fibrotic diseases�…
idiopathic pulmonary fibrosis is very common, the review focuses mainly on fibrotic diseases�…
[HTML][HTML] Fibrosis in chronic kidney disease: pathogenesis and consequences
S Panizo, L Mart�nez-Arias, C Alonso-Montes…�- International journal of�…, 2021 - mdpi.com
Fibrosis is a process characterized by an excessive accumulation of the extracellular matrix
as a response to different types of tissue injuries, which leads to organ dysfunction. The�…
as a response to different types of tissue injuries, which leads to organ dysfunction. The�…
[HTML][HTML] Fibrosis: types, effects, markers, mechanisms for disease progression, and its relation with oxidative stress, immunity, and inflammation
SA Antar, NA Ashour, ME Marawan…�- International Journal of�…, 2023 - mdpi.com
Most chronic inflammatory illnesses include fibrosis as a pathogenic characteristic.
Extracellular matrix (ECM) components build up in excess to cause fibrosis or scarring. The�…
Extracellular matrix (ECM) components build up in excess to cause fibrosis or scarring. The�…
Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies
I Lurje, NT Gaisa, R Weiskirchen, F Tacke�- Molecular Aspects of Medicine, 2023 - Elsevier
Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver�…
wound healing response and can occur in various organs such as the heart, lung, liver�…
[HTML][HTML] Multipotent stromal cells: one name, multiple identities
Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and
regeneration of most tissues. They can differentiate along multiple connective lineages, but�…
regeneration of most tissues. They can differentiate along multiple connective lineages, but�…
TGF‐β as a driver of fibrosis: physiological roles and therapeutic opportunities
EH Budi, JR Schaub, M Decaris, S Turner…�- The Journal of�…, 2021 - Wiley Online Library
Many chronic diseases are marked by fibrosis, which is defined by an abundance of
activated fibroblasts and excessive deposition of extracellular matrix, resulting in loss of�…
activated fibroblasts and excessive deposition of extracellular matrix, resulting in loss of�…
Transforming growth factor-β signaling: from tissue fibrosis to therapeutic opportunities
LL Ren, XJ Li, TT Duan, ZH Li, JZ Yang…�- Chemico-biological�…, 2023 - Elsevier
Fibrosis refers to the excessive deposition of extracellular matrix components in the
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in�…
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in�…
[HTML][HTML] T cells in fibrosis and fibrotic diseases
M Zhang, S Zhang�- Frontiers in immunology, 2020 - frontiersin.org
Fibrosis is the extensive deposition of fibrous connective tissue, and it is characterized by
the accumulation of collagen and other extracellular matrix (ECM) components. Fibrosis is�…
the accumulation of collagen and other extracellular matrix (ECM) components. Fibrosis is�…