Background There is accumulating evidence from preclinical studies that circulating
endothelial cells (CECs) play an important role in neovascularization and tumor growth. The�…

Vascularization, a hallmark of tumorigenesis, is classically thought to occur exclusively
through angiogenesis (ie endothelial sprouting). However, there is a growing body of�…

We show that mouse embryonic endothelial progenitor cells (eEPCs) home preferentially to
hypoxic lung metastases when administered intravenously. This specificity is inversely�…

Mammalian cells represent a novel vector approach for gene delivery that overcomes major
drawbacks of viral and nonviral vectors and couples cell therapy with gene delivery. A�…

Cell therapies are treatments in which stem or progenitor cells are stimulated to differentiate
into specialized cells able to home to and repair damaged tissues. After their discovery�…

Quantitative real-time PCR (qPCR) is a sensitive technique for the detection and quantitation
of specific DNA sequences. Here we describe a Taqman qPCR assay for quantification of�…

Over the last few years, naturally occurring or genetically manipulated oncolytic viruses
gained increasing attention as novel therapeutics for cancer treatment. The present work�…

Transforming growth factor-β (TGF-β) is a potent immunosuppressant. Overproduction of
TGF-β by tumor cells leads to evasion of host immune surveillance and tumor progression�…

A major limitation of cancer gene therapy is the difficulty of delivering a therapeutic gene to
distant sites of metastatic disease. A promising strategy to address this difficulty is to use�…

Endothelial progenitor cells (EPCs) are promising for cancer therapy because they
specifically target tumors. They have the capacity to home to, invade, migrate within and�…