For many pathologies associated with aging, female patients present with higher morbidity
and more frequent adverse events from treatments compared to male patients. While�…

Musculoskeletal diseases and injuries are among the leading causes of pain and morbidity
worldwide. Broad efforts have focused on developing pro‐regenerative biomaterials to treat�…

No current pharmacological approach is capable of simultaneously inhibiting the
symptomatology and structural progression of osteoarthritis. M1 macrophages and activated�…

Extracellular matrix (ECM) stiffening is a typical characteristic of cartilage aging, which is a
quintessential feature of knee osteoarthritis (KOA). However, little is known about how ECM�…

The mechanical elasticity or stiffness of the ECM modulates YAP activity to regulate the
differentiation of stem cells during the development and defect regeneration of cartilage�…

Great progress continues to be made in our understanding of the multiple facets of
osteoarthritis (OA) biology. Here, we review the major advances in this field and progress�…

Osteoarthritis (OA) is induced by matrix degradation and inflammation mediated by bromo-
domain-containing protein 4 (BRD4)-dependent catabolic factors. BRD4 acts as both a�…

Osteoarthritis is a leading cause of disability in the world. The scientific literature highlights
the critical importance of epigenetic regulatory effects, intertwined with biomechanical and�…

Mechanical perturbation triggers activation of resident myogenic stem cells to enter the cell
cycle through a cascade of events including hepatocyte growth factor (HGF) release from its�…

The availability of human cell-based models capturing molecular processes of cartilage
degeneration can facilitate development of disease-modifying therapies for osteoarthritis [1]�…