Neutrophil-directed motility is necessary for host defense, but its dysregulation can also
cause collateral tissue damage. Actinopathies are monogenic disorders that affect the actin�…

Inborn errors of immunity (IEI) are a group of diseases in humans that typically present as
increased susceptibility to infections, autoimmunity, hyperinflammation, allergy, and in some�…

Primary immunodeficiency (PID) disorders, also commonly referred to as inborn errors of
immunity, are a heterogenous group of human genetic diseases characterized by defects in�…

Actin network dynamics are pivotal in governing the motility and effector functions of immune
cells. The Arp2/3 complex is a key regulator of actin filament branching, with mutations in its�…

Cells are highly dynamic entities, which undergo continuous alterations in their shapes and
rapid re-organization of their inner workings. A key cellular component responsible for these�…

Actin-binding proteins (ABPs) have been established as important mediators of immune
homeostasis, but their effects on lymphocytes are poorly understood. Here, we�…

Cytotoxic lymphocytes are a subset of immune cells with key roles in host defense against
viral infections, against tumors as well as in self-regulation of immunity. Cytotoxic�…