Structures of mammalian RNA polymerase II pre-initiation complexes
S Aibara, S Schilbach, P Cramer�- Nature, 2021 - nature.com
The initiation of transcription is a focal point for the regulation of gene activity during
mammalian cell differentiation and development. To initiate transcription, RNA polymerase II�…
mammalian cell differentiation and development. To initiate transcription, RNA polymerase II�…
Three targets in one complex: A molecular perspective of TFIIH in cancer therapy
The general transcription factor II H (TFIIH) plays an essential role in transcription and
nucleotide excision DNA repair (NER). TFIIH is a complex 10 subunit containing molecular�…
nucleotide excision DNA repair (NER). TFIIH is a complex 10 subunit containing molecular�…
[HTML][HTML] Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II
Previous structural studies of the initiation-elongation transition of RNA polymerase II (pol II)
transcription have relied on the use of synthetic oligonucleotides, often artificially�…
transcription have relied on the use of synthetic oligonucleotides, often artificially�…
Everything at once: cryo-EM yields remarkable insights into human RNA polymerase II transcription
AC Schier, DJ Taatjes�- Nature structural & molecular biology, 2021 - nature.com
After years of only low-resolution and partial assemblies, the entire human preinitiation
complex (PIC), including the large and flexible Mediator and TFIID complexes, has come�…
complex (PIC), including the large and flexible Mediator and TFIID complexes, has come�…
[HTML][HTML] Ssl2/TFIIH function in transcription start site scanning by RNA polymerase II in Saccharomyces cerevisiae
In Saccharomyces cerevisiae, RNA polymerase II (Pol II) selects transcription start sites
(TSSs) by a unidirectional scanning process. During scanning, a preinitiation complex (PIC)�…
(TSSs) by a unidirectional scanning process. During scanning, a preinitiation complex (PIC)�…
[HTML][HTML] Editorial Overview: RNA polymerase II transcription
DJ Taatjes�- Journal of molecular biology, 2021 - ncbi.nlm.nih.gov
RNA polymerase II transcription is a fascinating area of research, with direct relevance to
human health and biotechnology. This special issue was organized around an ASBMB�…
human health and biotechnology. This special issue was organized around an ASBMB�…
Uncoupling the TFIIH Core and Kinase Modules Leads To Unregulated RNA Polymerase II CTD Serine 5 Phosphorylation
G Giordano, R Buratowski, C Jeronimo, C Poitras…�- bioRxiv, 2023 - biorxiv.org
TFIIH is an essential transcription initiation factor for RNA polymerase II (RNApII). This multi-
subunit complex comprises two modules that are physically linked by the subunit Tfb3�…
subunit complex comprises two modules that are physically linked by the subunit Tfb3�…