Beyond the pancreas: contrasting cardiometabolic actions of GIP and GLP1
R Hammoud, DJ Drucker�- Nature Reviews Endocrinology, 2023 - nature.com
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP1)
exhibit incretin activity, meaning that they potentiate glucose-dependent insulin secretion�…
exhibit incretin activity, meaning that they potentiate glucose-dependent insulin secretion�…
Glucagon-like peptide-1 receptor agonists and dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonists in the treatment of�…
EM Muzurović, Š Volčanšek…�- Journal of�…, 2022 - journals.sagepub.com
The obesity pandemic is accompanied by increased risk of developing metabolic syndrome
(MetS) and related conditions: non-alcoholic fatty liver disease (NAFLD)/non-alcoholic�…
(MetS) and related conditions: non-alcoholic fatty liver disease (NAFLD)/non-alcoholic�…
[HTML][HTML] Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist
Unimolecular triple incretins, combining the activity of glucagon-like peptide-1 (GLP-1),
glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCG), have�…
glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCG), have�…
Targeting the incretin/glucagon system with triagonists to treat diabetes
ME Capozzi, RD DiMarchi, MH Tsch�p…�- Endocrine�…, 2018 - academic.oup.com
Abstract Glucagonlike peptide 1 (GLP-1) receptor agonists have been efficacious for the
treatment of type 2 diabetes due to their ability to reduce weight and attenuate�…
treatment of type 2 diabetes due to their ability to reduce weight and attenuate�…
[HTML][HTML] Gut hormones and their effect on bone metabolism. Potential drug therapies in future osteoporosis treatment
SP Schiellerup, K Skov-Jeppesen…�- Frontiers in�…, 2019 - frontiersin.org
Bone homeostasis displays a circadian rhythm with increased resorption during the night
time as compared to day time, a difference that seems—at least partly—to be caused by food�…
time as compared to day time, a difference that seems—at least partly—to be caused by food�…
GIP and GLP-2 together improve bone turnover in humans supporting GIPR-GLP-2R co-agonists as future osteoporosis treatment
MBN Gabe, K Skov-Jeppesen, LS Gasbjerg…�- Pharmacological�…, 2022 - Elsevier
The intestinal hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-
like peptide-2 (GLP-2) are key regulators of postprandial bone turnover in humans. We�…
like peptide-2 (GLP-2) are key regulators of postprandial bone turnover in humans. We�…
Glucose-dependent insulinotropic polypeptide—a postprandial hormone with unharnessed metabolic potential
N Guccio, FM Gribble, F Reimann�- Annual review of nutrition, 2022 - annualreviews.org
Glucose-dependent insulinotropic polypeptide (GIP) is released from the upper small
intestine in response to food intake and contributes to the postprandial control of nutrient�…
intestine in response to food intake and contributes to the postprandial control of nutrient�…
Effects of endogenous GIP in patients with type 2 diabetes
S Stensen, LS Gasbjerg, LL Krogh…�- European Journal of�…, 2021 - academic.oup.com
Objective The insulinotropic effect of exogenous, intravenously infused glucose-dependent
insulinotropic polypeptide (GIP) is impaired in patients with type 2 diabetes. We evaluated�…
insulinotropic polypeptide (GIP) is impaired in patients with type 2 diabetes. We evaluated�…
Diabetes and calcification: the potential role of anti-diabetic drugs on vascular calcification regression
S Ghosh, D Luo, W He, J Chen, X Su…�- Pharmacological Research, 2020 - Elsevier
Vascular calcification (VC) has been well-established as an independent and strong
predictor of cardiovascular diseases (CVD) as well as major cardiac adverse events�…
predictor of cardiovascular diseases (CVD) as well as major cardiac adverse events�…
[HTML][HTML] Correlation of osteoporosis in patients with newly diagnosed type 2 diabetes: A retrospective study in Chinese population
Y Wen, H Li, X Zhang, P Liu, J Ma, L Zhang…�- Frontiers in�…, 2021 - frontiersin.org
This study aimed to explore the risk factors attributed to osteoporosis in newly type 2
diabetes mellitus (T2DM) patients. This study aimed to recruit 244 T2DM patients and 218�…
diabetes mellitus (T2DM) patients. This study aimed to recruit 244 T2DM patients and 218�…