Background Insulin shares a limited physiological concentration range with other endocrine
hormones. Not only too low, but also too high systemic insulin levels are detrimental for body�…

Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed
metalloprotease that degrades insulin and several other intermediate-size peptides. For�…

Purpose: To compare the efficiency of an aerobic physical training program prescribed
according to either velocity associated with maximum oxygen uptake (vVO2max) or peak�…

Impairment of the insulin-degrading enzyme (IDE) is associated with obesity and type 2
diabetes mellitus (T2DM). Here, we used 4-mo-old male C57BL/6 interleukin-6 (IL-6)�…

Hyperinsulinemia is frequently associated with aging and may cause insulin resistance in
elderly. Since insulin secretion and clearance decline with age, hyperinsulinemia seems to�…

SIRT3, the primary mitochondrial deacetylase, regulates the functions of mitochondrial
proteins including metabolic enzymes and respiratory chain components. Although SIRT3's�…

Alzheimer's disease (AD) is the most common form of dementia. With an aging population
and no disease modifying treatments available, AD is quickly becoming a global pandemic�…

Abstract Type 2 diabetes (T2D) risk is lower in females than males. It has been reported that
females have greater pancreatic 𝛽‐cell function than males, which may at least in part�…

SIRT3 deacetylates mitochondrial proteins, thereby enhancing their function. We have
previously demonstrated that Sirt3 gene deletion leads to brain mitochondrial dysfunction�…

Human islet amyloid polypeptide (hIAPP or amylin) is a hormone co-secreted with insulin by
pancreatic β-cells, and is the main component of islet amyloid. Islet amyloid is found in the�…