Commonalities in epileptogenic processes from different acute brain insults: Do they translate?
The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for�…
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for�…
Epilepsy biomarkers–toward etiology and pathology specificity
A biomarker is a characteristic that is measured as an indicator of normal biologic
processes, pathogenic processes, or responses to an exposure or intervention, including�…
processes, pathogenic processes, or responses to an exposure or intervention, including�…
Removing high-frequency oscillations: A prospective multicenter study on seizure outcome
Objective To evaluate the use of interictal high-frequency oscillations (HFOs) in epilepsy
surgery for prediction of postsurgical seizure outcome in a prospective multicenter trial�…
surgery for prediction of postsurgical seizure outcome in a prospective multicenter trial�…
Update on the mechanisms and roles of high‐frequency oscillations in seizures and epileptic disorders
High‐frequency oscillations (HFO s) are a type of brain activity that is recorded from brain
regions capable of generating seizures. Because of the close association of HFO s with�…
regions capable of generating seizures. Because of the close association of HFO s with�…
Identification of clinically relevant biomarkers of epileptogenesis—a strategic roadmap
M Simonato, DV Agoston, A Brooks-Kayal…�- Nature Reviews�…, 2021 - nature.com
Onset of many forms of epilepsy occurs after an initial epileptogenic insult or as a result of an
identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in�…
identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in�…
[HTML][HTML] Seizures in the neonate: A review of etiologies and outcomes
F Pisani, C Spagnoli, R Falsaperla, L Nagarajan…�- Seizure, 2021 - Elsevier
Neonatal seizures occur in their majority in close temporal relation to an acute brain injury or
systemic insult, and are accordingly defined as acute symptomatic or provoked seizures�…
systemic insult, and are accordingly defined as acute symptomatic or provoked seizures�…
Biomarkers for epileptogenesis and its treatment
J Engel Jr, A Pitk�nen�- Neuropharmacology, 2020 - Elsevier
There are no pharmacological interventions to prevent the development of epilepsy,
although many promising compounds have been identified in the animal laboratory. Clinical�…
although many promising compounds have been identified in the animal laboratory. Clinical�…
Post-traumatic epilepsy and comorbidities: advanced models, molecular mechanisms, biomarkers, and novel therapeutic interventions
Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that�…
consequences of traumatic brain injury (TBI). There is currently no approved treatment that�…
[HTML][HTML] Robust chronic convulsive seizures, high frequency oscillations, and human seizure onset patterns in an intrahippocampal kainic acid model in mice
CP Lisgaras, HE Scharfman�- Neurobiology of disease, 2022 - Elsevier
Intrahippocampal kainic acid (IHKA) has been widely implemented to simulate temporal
lobe epilepsy (TLE), but evidence of robust seizures is usually limited. To resolve this�…
lobe epilepsy (TLE), but evidence of robust seizures is usually limited. To resolve this�…
New approaches for developing multi-targeted drug combinations for disease modification of complex brain disorders. Does epilepsy prevention become a realistic�…
Over decades, the prevailing standard in drug discovery was the concept of designing highly
selective compounds that act on individual drug targets. However, more recently, multi-target�…
selective compounds that act on individual drug targets. However, more recently, multi-target�…