Autism spectrum disorders (ASDs) and related neurological disorders are associated with
mutations in many genes affecting the ratio between neuronal excitation and inhibition�…

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant�…

Epilepsy is one of the most common neurological disorders, yet its pathophysiology is poorly
understood due to the high complexity of affected neuronal circuits. To identify dysfunctional�…

Somatostatin-expressing GABAergic neurons constitute a major class of inhibitory neurons
in the mammalian cortex and are characterized by dense wiring into the local network and�…

GABAergic interneurons, which are highly diverse, have long been thought to contribute to
the timing of neural activity as well as to the generation and shaping of brain rhythms�…

Autism spectrum disorder (ASD) is strongly associated with de novo gene mutations. One of
the most commonly affected genes is SCN2A. ASD-associated SCN2A mutations impair the�…

Dravet syndrome (DS) is a severe epileptic encephalopathy caused mainly by heterozygous
loss-of-function mutations of the SCN1A gene, indicating haploinsufficiency as the�…

Epilepsy is a disease characterized by abnormal brain activity and a predisposition to
generate epileptic seizures, leading to neurobiological, cognitive, psychological, social, and�…

Epileptic seizures represent dysfunctional neural networks dominated by excessive and/or
hypersynchronous activity. Recent progress in the field has outlined two concepts regarding�…

Inhibitory interneurons regulate the oscillatory rhythms and network synchrony that are
required for cognitive functions and disrupted in Alzheimer's disease (AD). Network�…