From an evolutionary perspective keratan sulfate (KS) is the newest glycosaminoglycan
(GAG) but the least understood. KS is a sophisticated molecule with a diverse structure, and�…

Epilepsy is a chronic disease that affects millions of people worldwide. Antiepileptic drugs
(AEDs) are used to control seizures. Even though parts of their mechanisms of action are�…

In recent years, the field of neuroimaging dramatically moved forward by means of the
expeditious development of specific radioligands of novel targets. Among these targets, the�…

Prevention of epilepsy is a great unmet need. Acute central nervous system (CNS) insults
such as traumatic brain injury (TBI), cerebrovascular accidents (CVA), and CNS infections�…

The interplay between excitatory and inhibitory circuits underlies the brain's processes and
their dysregulation has been linked to cognitive decline, psychiatric disorders and epilepsy�…

The activity‐dependent fusion, retrieval and recycling of synaptic vesicles is essential for the
maintenance of neurotransmission. Until relatively recently it was believed that most�…

The laboratory rat has been used for a long time as the model of choice in several
biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide�…

Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear
demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam�…

Synaptic dysfunction and altered synaptic pruning are present in people with Parkinsonian
disorders. Dopamine loss and alpha‐synuclein accumulation, two hallmarks of Parkinson's�…

Abstract Synaptic Vesicle Protein 2 (SV2) comprises a recently evolved family of proteins
unique to secretory vesicles that undergo calcium-regulated exocytosis. In this review we�…